CAJ | 학술논문

从流动镶嵌模型到脂筏,细胞膜的结构模型研究不断进展.细胞膜的流动性是指构成细胞膜的脂质和蛋白质分子的运动性.对细胞膜流动性的观察方法包括自旋标记电子顺磁共振和荧光探针等.某些可溶性蛋白与细胞膜的相互作用,能改变其流动性.目前对于晶状体细胞膜流动性的研究十分有限,其脂质构成的特殊性,暗示了晶状体细胞膜流动性的特殊性.随年龄增长,晶状体核区细胞间弥散途径的建立,合胞体超结构的形成,可能需要其细胞膜流动性发生相应改变.以晶状体细胞膜流动性研究为切入点,有助于深入阐明白内障的发病机制.
종류동양감모형도지벌,세포막적결구모형연구불단진전.세포막적류동성시지구성세포막적지질화단백질분자적운동성.대세포막류동성적관찰방법포괄자선표기전자순자공진화형광탐침등.모사가용성단백여세포막적상호작용,능개변기류동성.목전대우정상체세포막류동성적연구십분유한,기지질구성적특수성,암시료정상체세포막류동성적특수성.수년령증장,정상체핵구세포간미산도경적건립,합포체초결구적형성,가능수요기세포막류동성발생상응개변.이정상체세포막류동성연구위절입점,유조우심입천명백내장적발병궤제.
From the fluid mosaic model to lipid rafts,the structural model of the cell membrane has been updating continuously.The cell membrane fluidity refers to the movement of lipid and protein molecules that construct the cell membrane together.Nowadays,there are several methods of fluidity observation through different mechanisms,such as spin labeling electron paramagnetic resonance and various fluorescent probes.The interaction of certain soluble proteins with the cell membrane can also alter its fluidity and other properties.For the lens cell membrane,there has been only limited research on its fluidity.The particular composition of lipids in lens cell membrane implies the special nature of its fluidity.As age is increasing,the fluidity of lens membrane changes accordingly,leading to the establishment of the diffusion pathways among the cells in the nuclear region,and the formation of syncytial ultrastructure.The analysis of the fluidity of lens cell membrane will be helpful in the future for further clarifying the pathogenesis of cataract.