CAJ | 학술논문

糖尿病视网膜病变(diabetic retinopathy,DR)的病理机制一直是研究的热点.经典理论认为视网膜微血管病变是DR最早的超微结构改变,但近年的研究表明,血-视网膜屏障的破坏和神经变性在DR的早期病变中也发挥着举足轻重的作用.甚至有学者发现在视网膜微血管病变以前就已出现了神经元的大量凋亡和胶质细胞的活化.
당뇨병시망막병변(diabetic retinopathy,DR)적병리궤제일직시연구적열점.경전이론인위시망막미혈관병변시DR최조적초미결구개변,단근년적연구표명,혈-시망막병장적파배화신경변성재DR적조기병변중야발휘착거족경중적작용.심지유학자발현재시망막미혈관병변이전취이출현료신경원적대량조망화효질세포적활화.
The pathological mechanisms of diabetic retinopathy (DR) have always been a research hot topic.It has been believed that retinal microvascular lesions are the earliest pathological change in DR.But recently,studies showed that blood-retinal barrier damage and nerve degeneration also play a decisive role in early DR pathological changes.Some authors found that a large number of apoptotic neurons and activated microglial cells appeared before the retinal microvascular lesions happened.Because early DR analysis is of great value for clinical diagnosis and treatment,this article reviews the research advances in early diabetic retinopathy physiopathology.