国际眼科纵览
國際眼科縱覽
국제안과종람
OREIGN MEDICAL SCIENCES
2013年
2期
129-134
,共6页
近视眼%动物模型%形觉剥夺%离焦
近視眼%動物模型%形覺剝奪%離焦
근시안%동물모형%형각박탈%리초
myopia%animal model%form deprivation%defocus-induced
近视眼对眼底形态及视功能呈进行性损害,它的发生机制成为眼科的研究热点,动物模型的建立为一些受限于伦理和实验手段而无法进行的研究提供了良好的受试对象和实验平台.近年来,学者们采用鸡、小鼠、树鼩、豚鼠、兔、猴等动物模型,对远视性离焦和近视性离焦对幼年动物眼的影响,视觉发育的双向调节作用,昼夜节律、不同光谱对眼轴延长的影响,以及与眼轴延长相关的细胞因子等进行了大量研究.
近視眼對眼底形態及視功能呈進行性損害,它的髮生機製成為眼科的研究熱點,動物模型的建立為一些受限于倫理和實驗手段而無法進行的研究提供瞭良好的受試對象和實驗平檯.近年來,學者們採用鷄、小鼠、樹鼩、豚鼠、兔、猴等動物模型,對遠視性離焦和近視性離焦對幼年動物眼的影響,視覺髮育的雙嚮調節作用,晝夜節律、不同光譜對眼軸延長的影響,以及與眼軸延長相關的細胞因子等進行瞭大量研究.
근시안대안저형태급시공능정진행성손해,타적발생궤제성위안과적연구열점,동물모형적건립위일사수한우윤리화실험수단이무법진행적연구제공료량호적수시대상화실험평태.근년래,학자문채용계、소서、수구、돈서、토、후등동물모형,대원시성리초화근시성리초대유년동물안적영향,시각발육적쌍향조절작용,주야절률、불동광보대안축연장적영향,이급여안축연장상관적세포인자등진행료대량연구.
Myopia progressively damages ocular fundus morphology and visual function.Its mechanisms is a research hotspot in Ophthalmology.The establishment of an animal model for the study of myopia provides a good experimental platform,which is not limited by ethical and experimental means.Various animal models,have been developed such as domestic chickens,mice,tree shrew,guinea pigs,rabbits or marmosets.The effect of hyperopic and myopic defocus to animal eyes,the two-ways regulation effect on visual development,the influence of circadian rhythm,the different spectral eye axis growth and the axial growth related cytokines are currently investigated.
