国际移植与血液净化杂志
國際移植與血液淨化雜誌
국제이식여혈액정화잡지
INTERNATIONAL JOURNAL OF TRANSPLANTATION AND HEMOPURIFICATION
2012年
6期
16-18
,共3页
程新%袁一孟%黄仁发%赖申昌%马晓露%吴潇云
程新%袁一孟%黃仁髮%賴申昌%馬曉露%吳瀟雲
정신%원일맹%황인발%뢰신창%마효로%오소운
血液透析%血液透析滤过%血液灌流%终未期肾病%难治性高血压
血液透析%血液透析濾過%血液灌流%終未期腎病%難治性高血壓
혈액투석%혈액투석려과%혈액관류%종미기신병%난치성고혈압
Hemodialysis%Hemodiafiltration%Blood perfusion%End stage renal disease%Refractory hypertension
目的 不同血液净化方法治疗维持性血液透析患者难治性高血压的疗效观察.方法 60例终未期肾病难治性高血压患者按随机数字表法分为血液透析组,血液透析联合血液透析滤过组,血液透析联合血液灌流组,每组15例患者.血液透析联合血液透析滤过再联合血液灌流组,观察治疗前及治疗16周后所有患者血压变化及肾素、血管紧张素Ⅱ、全段甲状旁腺激素的水平变化.结果 各组患者治疗后血压及肾素、血管紧张素Ⅱ、全段甲状旁腺激素水平与治疗前比较差异有统计学意义(P＜0.05),而治疗组中血液透析联合血液透析滤过再联合血液灌流组与血液透析联合血液灌流组、血液透析联合血液透析滤过组治疗后比较,血压变化及肾素、血管紧张素Ⅱ、全段甲状旁腺激素水平与治疗前比较差异有统计学意义(P＜0.05).结论 在维持血液透析的治疗基础上联合应用血液透析滤过及血液灌流能有效的控制终未期肾病难治性高血压.
目的 不同血液淨化方法治療維持性血液透析患者難治性高血壓的療效觀察.方法 60例終未期腎病難治性高血壓患者按隨機數字錶法分為血液透析組,血液透析聯閤血液透析濾過組,血液透析聯閤血液灌流組,每組15例患者.血液透析聯閤血液透析濾過再聯閤血液灌流組,觀察治療前及治療16週後所有患者血壓變化及腎素、血管緊張素Ⅱ、全段甲狀徬腺激素的水平變化.結果 各組患者治療後血壓及腎素、血管緊張素Ⅱ、全段甲狀徬腺激素水平與治療前比較差異有統計學意義(P＜0.05),而治療組中血液透析聯閤血液透析濾過再聯閤血液灌流組與血液透析聯閤血液灌流組、血液透析聯閤血液透析濾過組治療後比較,血壓變化及腎素、血管緊張素Ⅱ、全段甲狀徬腺激素水平與治療前比較差異有統計學意義(P＜0.05).結論 在維持血液透析的治療基礎上聯閤應用血液透析濾過及血液灌流能有效的控製終未期腎病難治性高血壓.
목적 불동혈액정화방법치료유지성혈액투석환자난치성고혈압적료효관찰.방법 60례종미기신병난치성고혈압환자안수궤수자표법분위혈액투석조,혈액투석연합혈액투석려과조,혈액투석연합혈액관류조,매조15례환자.혈액투석연합혈액투석려과재연합혈액관류조,관찰치료전급치료16주후소유환자혈압변화급신소、혈관긴장소Ⅱ、전단갑상방선격소적수평변화.결과 각조환자치료후혈압급신소、혈관긴장소Ⅱ、전단갑상방선격소수평여치료전비교차이유통계학의의(P＜0.05),이치료조중혈액투석연합혈액투석려과재연합혈액관류조여혈액투석연합혈액관류조、혈액투석연합혈액투석려과조치료후비교,혈압변화급신소、혈관긴장소Ⅱ、전단갑상방선격소수평여치료전비교차이유통계학의의(P＜0.05).결론 재유지혈액투석적치료기출상연합응용혈액투석려과급혈액관류능유효적공제종미기신병난치성고혈압.
Objective To investigate the treatment effect of various blood purification methods in combination therapy in hemodialysis patients with refractory hypertension.Methods 60 patients with end stage renal disease refractory hypertension were randomly divided into 4 groups:control group,the hemodialysis group (HD),treatment group were divided into 3 groups:combined Hemodialysis hemodiafiltration group (HD + HDF),blood dialysis on blood perfusion group (HD + HP),blood dialysis and hemodiafiltration and then combined blood perfusion group(HD + HP + HP),Observe before treatment and after 8 weeks of treatment blood pressure and rennin-angiotensin (RA),angiotensin (Ang Ⅱ),Intact parathyroid hormone (iPTH) level.Results Before treatment,the observation indexes were no significant differences control group and treatment group,before and after treatment showed significant change both in the observation indexes,blood pressure and RA,AngⅡ,iPTH levels were significantly decreased (P ＜ 0.05).the three treatment groups compared with the control group blood pressure and Ang Ⅱ,iPTH levels were significantly decreased (P＜0.05),in the treatment group HD+ HDF+ Hp group and HD + HP group,HD + HDF group after treatment compared,blood pressure and RA,Ang Ⅱ,iPTH levels were significantly decreased (P ＜ 0.05).Conclusions Based on the maintenance of the treatment of hemodialysis combined hemodiafiltration and blood perfusion can effectively control refractory end stage renal disease hypertension.
