国际移植与血液净化杂志
國際移植與血液淨化雜誌
국제이식여혈액정화잡지
INTERNATIONAL JOURNAL OF TRANSPLANTATION AND HEMOPURIFICATION
2013年
3期
33-35
,共3页
郭东花%李红梅%李颖%高海英%王玉杰%郭晨涛
郭東花%李紅梅%李穎%高海英%王玉傑%郭晨濤
곽동화%리홍매%리영%고해영%왕옥걸%곽신도
高通量透析%血液透析滤过%维持性血液透析%甲状旁腺激素
高通量透析%血液透析濾過%維持性血液透析%甲狀徬腺激素
고통량투석%혈액투석려과%유지성혈액투석%갑상방선격소
High-flux hemodialysis%Hemodiafiltration%Maintenance hemodialysis%Parathyroid hormone
目的 血清甲状旁腺激素的蓄积在透析相关甲状旁腺机能亢进症的发病中起了重要的作用.高通量透析和血液透析滤过均可有效清除甲状旁腺激素.本研究的目的是比较高通量透析联合血液透析滤过与高通量透析及低通量透析对甲状旁腺激素的清除效果.方法 将在我院进行持续性血液透析治疗的36例患者[男20例,女16例,年龄21 ～ 78岁,平均(55±15)岁]随机分至A组(n=12,接受高通量透析+血液透析滤过)、B组(n=12,接受高通量透析)及C组(n=12,接受低通量透析).高通量透析采用Niprol50DS透析器,血液透析滤过采用HF80S透析器,低通量透析采用金宝14L透析器.观察12个月后各组患者血钙、血磷、血清甲状旁腺激素、血清碱性磷酸酶、血清肌酐、尿素氮及白蛋白的变化.结果 各组治疗前后血钙无明显变化,A组血磷有所下降,A组及B组透析治疗后甲状旁腺激素有不同程度的下降.结论 高通量透析联合血液透析滤过及单一高通量透析均可降低持续性血液透析者甲状旁腺激素水平,改善钙磷代谢异常,减轻甲状旁腺机能亢进症.
目的 血清甲狀徬腺激素的蓄積在透析相關甲狀徬腺機能亢進癥的髮病中起瞭重要的作用.高通量透析和血液透析濾過均可有效清除甲狀徬腺激素.本研究的目的是比較高通量透析聯閤血液透析濾過與高通量透析及低通量透析對甲狀徬腺激素的清除效果.方法 將在我院進行持續性血液透析治療的36例患者[男20例,女16例,年齡21 ～ 78歲,平均(55±15)歲]隨機分至A組(n=12,接受高通量透析+血液透析濾過)、B組(n=12,接受高通量透析)及C組(n=12,接受低通量透析).高通量透析採用Niprol50DS透析器,血液透析濾過採用HF80S透析器,低通量透析採用金寶14L透析器.觀察12箇月後各組患者血鈣、血燐、血清甲狀徬腺激素、血清堿性燐痠酶、血清肌酐、尿素氮及白蛋白的變化.結果 各組治療前後血鈣無明顯變化,A組血燐有所下降,A組及B組透析治療後甲狀徬腺激素有不同程度的下降.結論 高通量透析聯閤血液透析濾過及單一高通量透析均可降低持續性血液透析者甲狀徬腺激素水平,改善鈣燐代謝異常,減輕甲狀徬腺機能亢進癥.
목적 혈청갑상방선격소적축적재투석상관갑상방선궤능항진증적발병중기료중요적작용.고통량투석화혈액투석려과균가유효청제갑상방선격소.본연구적목적시비교고통량투석연합혈액투석려과여고통량투석급저통량투석대갑상방선격소적청제효과.방법 장재아원진행지속성혈액투석치료적36례환자[남20례,녀16례,년령21 ～ 78세,평균(55±15)세]수궤분지A조(n=12,접수고통량투석+혈액투석려과)、B조(n=12,접수고통량투석)급C조(n=12,접수저통량투석).고통량투석채용Niprol50DS투석기,혈액투석려과채용HF80S투석기,저통량투석채용금보14L투석기.관찰12개월후각조환자혈개、혈린、혈청갑상방선격소、혈청감성린산매、혈청기항、뇨소담급백단백적변화.결과 각조치료전후혈개무명현변화,A조혈린유소하강,A조급B조투석치료후갑상방선격소유불동정도적하강.결론 고통량투석연합혈액투석려과급단일고통량투석균가강저지속성혈액투석자갑상방선격소수평,개선개린대사이상,감경갑상방선궤능항진증.
Objective The accumulation of serum parathyroid hormone (PTH) plays an important role in the pathogenesis of dialysis-related secondary hyperparathyroidism (SHPT).Both high-flux hemodialysis (HFHD) and hemodiafiltration (HDF) can effectively remove PTH.This investigation was to compare the efficacy of HFHD + HDF vs HFHD or low-flux hemodialysis (LFHD) on the removal of PTH.Methods A total of 36 patients who underwent maintenance hemodialysis were randomly assigned to the HFHD+ HDF group (n =12),the HFHD group (n =12) and the LFHD group (n =12).Nipro150DS,HF80S and Gambro's 14L dialyzer was used for HFHD,HDF and LFHD,respectively.After 12 months'treatment,serum calcium,phosphorus,PTH,alkaline phosphatase (AKP),BUN,Scr and albumin (ALB)were observed.Results All the three groups showed no significant changes in serum calcium before and after the intervention.Serum phosphorus of the HFHD + HDF group was slightly declined.PTH of both the HFHD + HDF and the HFHD group was decreased to some extent.Conclusion Both HFHD + HDF and HFHD could reduce serum PTH of patients who are receiving maintenance hemodialysis.
