CAJ | 학술논문

目前研究提示紫杉类耐药可能与多药耐药相关蛋白(MRP)表达增高、Ⅲβ-微管过表达、微管相关蛋白tau的过表达有关,而与HER2的表达成负相关.针对这些耐药靶点可逆转或者延缓紫杉类药物耐药的发生,为临床上更好地使用紫杉类药物提供一定参考.
목전연구제시자삼류내약가능여다약내약상관단백(MRP)표체증고、Ⅲβ-미관과표체、미관상관단백tau적과표체유관,이여HER2적표체성부상관.침대저사내약파점가역전혹자연완자삼류약물내약적발생,위림상상경호지사용자삼류약물제공일정삼고.
Recent studies show that taxanes resistances may be positively associated with overexpression of MRP protein,the change of β-microtuble,thus negatively associated with the expression of HER-2.The therapies which are specific to these targets will reverse or postpone the occurrence of drug resistance and provide more evidences on the better use of taxanes in clinic.