CAJ | 학술논문

埃兹蛋白(Ezrin)不仅参与细胞形态的维持、细胞运动及黏附过程,而且参与肿瘤侵袭和转移的多个环节.Ezrin蛋白在肿瘤转移中参与多个肿瘤相关信号通路如Rho介导的信号转导通路、肝细胞生长因子(HGF)通路、Fas介导的细胞凋亡信号通路、磷脂酰肌醇-3激酶(PI3K)-蛋白激酶C(Akt)通路等,并在其中发挥不同的调节作用.
애자단백(Ezrin)불부삼여세포형태적유지、세포운동급점부과정,이차삼여종류침습화전이적다개배절.Ezrin단백재종류전이중삼여다개종류상관신호통로여Rho개도적신호전도통로、간세포생장인자(HGF)통로、Fas개도적세포조망신호통로、린지선기순-3격매(PI3K)-단백격매C(Akt)통로등,병재기중발휘불동적조절작용.
Ezrin protein plays an important role in morphogenesis,motility,adhesion.Moreover,Ezrin protein participates in multiple steps of the process of tumor invasion and metastasis.In the progress of tumor metastasis,Ezrin protein is related to several signaling pathways such as Rho mediated signaling pathways,hepatocyte growth factor (HGF) pathways,Fas mediated cell apoptosis signaling pathways,phosphatidyl inositol 3-kinase (PI3K)-Akt pathways,and in which it plays different regulatory role.