CAJ | 학술논문

Wnt信号通路不仅与肿瘤侵袭转移的相关事件如癌细胞的迁移黏附、细胞外基质的降解及肿瘤的血管生成密切相关,而且在调节肿瘤干细胞的自我更新、增殖与分化中发挥重要作用,并且针对Wnt信号通路不同基因靶点的高特异性基因药物开发及其肿瘤靶向治疗方面也取得一定进展.
Wnt신호통로불부여종류침습전이적상관사건여암세포적천이점부、세포외기질적강해급종류적혈관생성밀절상관,이차재조절종류간세포적자아경신、증식여분화중발휘중요작용,병차침대Wnt신호통로불동기인파점적고특이성기인약물개발급기종류파향치료방면야취득일정진전.
Wnt signaling pathway is not only closely related to tumor invasion and metastasis,such as cancer cells migration and adhesion,extracellular matrix degradation,and angiogenesis,but also plays an important role in self-renewal,proliferation and differentiation of tumor stem cells.Progress has been made in high specific genes drug development and targeted therapy against the Wnt signaling pathway.