CAJ | 학술논문

聚ADP核糖聚合酶(PARP)在DNA损伤修复、维持基因组稳定性方面起着重要作用.因此PARP抑制剂能够抑制肿瘤细胞DNA损伤修复、增强肿瘤细胞DNA对损伤因素的敏感性.近年来PARP抑制剂的研究受到了越来越多的关注.PARP抑制剂单药可以在具有某些基因突变的肿瘤中发挥合成致死作用,与化疗或放疗联合能够增加肿瘤细胞对化疗或放疗的敏感性.PARP抑制剂有望在肿瘤治疗领域中发挥重要作用.
취ADP핵당취합매(PARP)재DNA손상수복、유지기인조은정성방면기착중요작용.인차PARP억제제능구억제종류세포DNA손상수복、증강종류세포DNA대손상인소적민감성.근년래PARP억제제적연구수도료월래월다적관주.PARP억제제단약가이재구유모사기인돌변적종류중발휘합성치사작용,여화료혹방료연합능구증가종류세포대화료혹방료적민감성.PARP억제제유망재종류치료영역중발휘중요작용.
Poly ADP ribose polymerases (PARP) play an important role in DNA damage repair and genome stability.So,PARP inhibitors can inhibit the DNA damage repairing of tumor cells and enhance the sensitivity of the DNA of tumor cells to damage factors.In recent years,PARP inhibitors have been more and more concerned.PARP inhibitors can kill tumor cells with certain genetic mutations alone by synthetic lethal effect.In addition,PARP inhibitors in combination with chemotherapy or radiotherapy can increase the sensi tivity of tumor cells to the chemotherapy or radiotherapy.PARP inhibitors are expected to play an important role in cancer therapy.