国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2012年
11期
854-857
,共4页
胃肿瘤%西罗莫司%哺乳动物雷帕霉素靶蛋白
胃腫瘤%西囉莫司%哺乳動物雷帕黴素靶蛋白
위종류%서라막사%포유동물뢰파매소파단백
Stomach neoplasms%Sirolimus%Mammalian target of rapamycin
哺乳动物雷帕霉素靶蛋白(mTOR)信号途径在多种恶性肿瘤中存在异常激活或变异,该途径激活可以调控肿瘤细胞的增殖、存活以及转移能力,进而导致恶性肿瘤发生发展.雷帕霉素及其衍生物通过阻断mTOR通路的信号传递,抑制胃癌细胞生长,促进肿瘤坏死,并能与其他化疗药物产生协同作用,有望为胃癌预防和治疗提供有效的方法.
哺乳動物雷帕黴素靶蛋白(mTOR)信號途徑在多種噁性腫瘤中存在異常激活或變異,該途徑激活可以調控腫瘤細胞的增殖、存活以及轉移能力,進而導緻噁性腫瘤髮生髮展.雷帕黴素及其衍生物通過阻斷mTOR通路的信號傳遞,抑製胃癌細胞生長,促進腫瘤壞死,併能與其他化療藥物產生協同作用,有望為胃癌預防和治療提供有效的方法.
포유동물뢰파매소파단백(mTOR)신호도경재다충악성종류중존재이상격활혹변이,해도경격활가이조공종류세포적증식、존활이급전이능력,진이도치악성종류발생발전.뢰파매소급기연생물통과조단mTOR통로적신호전체,억제위암세포생장,촉진종류배사,병능여기타화료약물산생협동작용,유망위위암예방화치료제공유효적방법.
Aberrations of the mammalian target of rapamycin (mTOR) signaling are frequently observed in many types of cancer.Activation of mTOR regulates tumor cell proliferation,survival and metastasis,and then results tumorigenesis and tumor developmet.Blocking the mTOR signaling pathway by rapamycin and its derivatives can inhibit gastric cancer cell growth and promote tumor necrosis and such effects can be synergistically improved by combined use of other chemotherapeutic agents.Thus,rapamyein and its derivatives may be effective in the prevention and treatment of gastric cancer.