CAJ | 학술논문

髓样抑制性细胞(MDSC)是一组来源于未成熟髓系细胞不同分化阶段的异质性细胞群体,可通过抑制T细胞及自然杀伤(NK)细胞的活性、诱导T-regs细胞的产生、参与肿瘤血管生成等多种途径诱导免疫抑制、介导免疫耐受,在肿瘤的发展和转移方面发挥着重要的作用.运用各种方法促进MDSC分化成熟,减少其数量、抑制其功能等可能有助于肿瘤患者正常免疫状态的恢复,控制肿瘤的进展,提高其他抗肿瘤治疗的疗效.靶向MDSC已成为肿瘤免疫治疗的新思路.
수양억제성세포(MDSC)시일조래원우미성숙수계세포불동분화계단적이질성세포군체,가통과억제T세포급자연살상(NK)세포적활성、유도T-regs세포적산생、삼여종류혈관생성등다충도경유도면역억제、개도면역내수,재종류적발전화전이방면발휘착중요적작용.운용각충방법촉진MDSC분화성숙,감소기수량、억제기공능등가능유조우종류환자정상면역상태적회복,공제종류적진전,제고기타항종류치료적료효.파향MDSC이성위종류면역치료적신사로.
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells at different stages of maturation.MDSCs mediate the suppression of the anti-tumor immunity,and play a crucial role in cancer tolerance through suppressing the activity of T cells and natural killer cells,inducing T-regs and involving the angiogenesis,and then contribute to the tumor development and metastasis.Promoting the differentiation of MDSCs,reducing its quantity and inhibiting its function by using various methods may contribute to the recovery of patients normal immune status,the tumor progression control,and improvement of the efficacy of other anti-neoplastic therapies.Therefore,possible novel therapeutic approaches targeted at MDSCs could be considered and developed rapidly now.