CAJ | 학술논문

研究发现Ⅲ型干扰素(IFN-λ)具有抗黑色素瘤、肝细胞癌、食管癌、纤维素瘤等的作用.IFN-λ不仅能抑制黑色素瘤的转移,还可引起细胞凋亡；组成性表达的IFN-λ使自然杀伤细胞活化,从而影响肝细胞癌的生长；在食管癌中,IFN-λ能诱导G1期细胞的停滞或直接导致细胞凋亡；IFN-λ可通过诱导固有免疫和适应性免疫反应来抑制体内纤维肉瘤的生长.这些抗肿瘤机制的研究为IFN-λ运用于肿瘤临床治疗提供了新的思路.
연구발현Ⅲ형간우소(IFN-λ)구유항흑색소류、간세포암、식관암、섬유소류등적작용.IFN-λ불부능억제흑색소류적전이,환가인기세포조망；조성성표체적IFN-λ사자연살상세포활화,종이영향간세포암적생장；재식관암중,IFN-λ능유도G1기세포적정체혹직접도치세포조망；IFN-λ가통과유도고유면역화괄응성면역반응래억제체내섬유육류적생장.저사항종류궤제적연구위IFN-λ운용우종류림상치료제공료신적사로.
It is reported that type Ⅲ interferon (IFN-λ) has an anti-tumor effect on melanoma,hepatocellular carcinoma,esophageal carcinoma and fibrosarcoma in recent years.IFN-λ could not only inhibit melanoma metastasis,but also induce cell apoptosis;its constitutively expression could activate natural killer cells,affecting hepatocellular carcinoma growth;IFN-λ could induce cells of G1 phase in esophageal carcinoma directly to stagnation or apoptosis;IFN-λ could cause native and adaptive immune response to suppress fibrosarcoma growth.Research on the anti-tumor mechanisms of IFN-λ will provide new ideas for clinical tumor therapy.