CAJ | 학술논문

双膦酸盐能减少乳腺癌骨转移中骨相关事件的发生,预防早期乳腺癌治疗引起的骨丢失、增加骨密度；清除骨髓播散肿瘤细胞和循环中的肿瘤细胞,防止乳腺癌复发和转移；减轻早期乳腺癌新辅助化疗的肿瘤负荷,改善病理完全缓解率.双膦酸盐在早期乳腺癌辅助治疗的研究结果中存在差异,主要获益亚组为绝经后低雌激素水平患者.
쌍련산염능감소유선암골전이중골상관사건적발생,예방조기유선암치료인기적골주실、증가골밀도；청제골수파산종류세포화순배중적종류세포,방지유선암복발화전이；감경조기유선암신보조화료적종류부하,개선병리완전완해솔.쌍련산염재조기유선암보조치료적연구결과중존재차이,주요획익아조위절경후저자격소수평환자.
Bisphosphonates are commonly used in patients with breast cancer to reduce skeletal-related events in metastatic disease,mitigate bone loss,and increase bone mineral density.Bisphosphonates can decrease and cleare disseminated tumor cells in bone marrow and circulation tumor cells and then prevent breast cancer relapse and metastases.Bisphosphonates can lighten tumor burden in the breast when administered with neoadjuvant chemotherapy,and improve pathology complete remission rates.Inconsistence is observed in large trials using bisphosphonates in the adjuvant setting of early breast cancer,but survival improvement is mostly seen in postmenopausal patients with low levels of estrogens.