国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2012年
12期
935-938
,共4页
微卫星不稳定性%结直肠肿瘤%预后%药物疗法
微衛星不穩定性%結直腸腫瘤%預後%藥物療法
미위성불은정성%결직장종류%예후%약물요법
Microsatellite instability%Colorectal neoplasms%Prognosis%Drug therapy
微卫星不稳定性(MSI)是结直肠癌发生发展的重要分子机制,对结直肠癌具有重要临床意义.MSI是林奇综合征的诊断标志物.同时由于MSI阳性的结直肠癌比阴性者表现出更好的预后,且对5-氟尿嘧啶类化疗药物不敏感,MSI同样成为结直肠癌的预后和预测化疗疗效的标志物.
微衛星不穩定性(MSI)是結直腸癌髮生髮展的重要分子機製,對結直腸癌具有重要臨床意義.MSI是林奇綜閤徵的診斷標誌物.同時由于MSI暘性的結直腸癌比陰性者錶現齣更好的預後,且對5-氟尿嘧啶類化療藥物不敏感,MSI同樣成為結直腸癌的預後和預測化療療效的標誌物.
미위성불은정성(MSI)시결직장암발생발전적중요분자궤제,대결직장암구유중요림상의의.MSI시림기종합정적진단표지물.동시유우MSI양성적결직장암비음성자표현출경호적예후,차대5-불뇨밀정류화료약물불민감,MSI동양성위결직장암적예후화예측화료료효적표지물.
Microsatellite instability (MSI) is an important molecular mechanism in colorectal cancer's initiation and progression,which has significant clinical significance.MSI is a diagnostic biomarker for Lynch synchrome.Moreover,the clinical implication of MSI testing extends to the role of prognostic marker and predictive maker,due to the better outcome of patients with MSI positive colorectal cancer and a general lack of response to chemotherapy employing 5-fluorouracil.
