CAJ | 학술논문

目的探讨基质金属蛋白酶9 (MMP-9)基因rs3918242位点多态性与肿瘤易感性的关系.方法使用PubMed数据库检索2011年4月以前相关文献,按纳入标准搜索研究MMP-9 rs3918242 C/T多态性与肿瘤易感性相关的文献,采用STATA软件进行统计分析.结果共有4 124例肿瘤患者和4 728名对照个体被纳入荟萃分析.分析表明MMP-9 rs3918242 C/T多态性与整个肿瘤易感性无显著相关(等位基因比P=0.378,OR=0.94,95％ CI:0.83 ～ 1.07),但在肿瘤分层分析中发现MMP-9突变型等位基因T显著降低了肺癌(P =0.026,OR=0.70,95％ CI:0.51 ～0.96)和结直肠癌(P=0.016,OR=0.80,95％ CI:0.66 ～ 0.96)的易感性.结论 MMP-9 rs3918242 C/T多态性与结直肠癌和肺癌易感性存在一定的相关性.
목적 탐토기질금속단백매9 (MMP-9)기인rs3918242위점다태성여종류역감성적관계.방법 사용PubMed수거고검색2011년4월이전상관문헌,안납입표준수색연구MMP-9 rs3918242 C/T다태성여종류역감성상관적문헌,채용STATA연건진행통계분석.결과 공유4 124례종류환자화4 728명대조개체피납입회췌분석.분석표명MMP-9 rs3918242 C/T다태성여정개종류역감성무현저상관(등위기인비P=0.378,OR=0.94,95％ CI:0.83 ～ 1.07),단재종류분층분석중발현MMP-9돌변형등위기인T현저강저료폐암(P =0.026,OR=0.70,95％ CI:0.51 ～0.96)화결직장암(P=0.016,OR=0.80,95％ CI:0.66 ～ 0.96)적역감성.결론 MMP-9 rs3918242 C/T다태성여결직장암화폐암역감성존재일정적상관성.
Objective To study the correlation between MMP-9 rs3918242 C ＞ T polymorphism and cancer risk.Methods PubMed database was utilized to search the relative artiles concerning association between MMP-9 rs3918242 C ＞T polymorphism and cancer risk (last search updated on April 2011).All the statistical analysis was performed by STATA software.Results 4,124 cancer patients and 4,728 control subjects were included in this meta-analysis.No association was observed in the overall analysis (allelic contrast P=0.378,OR =0.94,95％ CI:0.83-1.07).However,in the stratified analysis by cancer type,MMP-9-1562 T allele was found to decrease the lung cancer(P =0.026,OR =0.70,95％ CI:0.5 1-0.96) and colorectal cancer(P=0.016,OR =0.80,95％ CI:0.66-0.96).Conclusion MMP-9 rs3918242 C/T polymorphism is correlated with colorectal cancer and lung cancer.