国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2013年
1期
43-46
,共4页
肺肿瘤%肿瘤形成过程%抗药性%醛酮还原酶超家族
肺腫瘤%腫瘤形成過程%抗藥性%醛酮還原酶超傢族
폐종류%종류형성과정%항약성%철동환원매초가족
Lung neoplasms%Neoplastic processes%Drug resistance%Aldo-keto reductase superfamily
醛酮还原酶(AKR)超家族是烟酰胺腺嘌呤二核苷酸磷酸(NADPH)依赖的氧化还原酶,作为多元醇代谢通路的限速酶,其活化或失活参与外界毒物代谢相关的肺癌的发生,并与肺癌抗药性产生相关,成为肺癌预后预测的相关因子.
醛酮還原酶(AKR)超傢族是煙酰胺腺嘌呤二覈苷痠燐痠(NADPH)依賴的氧化還原酶,作為多元醇代謝通路的限速酶,其活化或失活參與外界毒物代謝相關的肺癌的髮生,併與肺癌抗藥性產生相關,成為肺癌預後預測的相關因子.
철동환원매(AKR)초가족시연선알선표령이핵감산린산(NADPH)의뢰적양화환원매,작위다원순대사통로적한속매,기활화혹실활삼여외계독물대사상관적폐암적발생,병여폐암항약성산생상관,성위폐암예후예측적상관인자.
Aldo-keto reductase reductase (AKR) superfamily is NADPH-dependent oxidoreductase.As a rate-limiting enzyme in polyols metabolic pathway,the activation or inactivation of AKR involves in neoplastic process of lung cancer with the metabolism of environment toxic.AKR is related to drug resistance of chemotherapy,which will be the prognostic factor of lung cancer.
