CAJ | 학술논문

FLIP是一种含有死亡结构域的蛋白质,人类有3个亚型c-FLIPL、c-FLIPS和c-FLIPR,是多种肿瘤细胞抑制凋亡的主要蛋白,其中c-FLIPL在细胞凋亡信号中起双重作用.FLIP的表达高低不仅可以决定细胞凋亡通路的开闭,同时也能实现细胞在凋亡信号与增殖信号通路间的转换.FLIP表达的调控是多层次的,涉及多条信号通路,有可能成为极具吸引力的死亡受体信号的治疗靶点.
FLIP시일충함유사망결구역적단백질,인류유3개아형c-FLIPL、c-FLIPS화c-FLIPR,시다충종류세포억제조망적주요단백,기중c-FLIPL재세포조망신호중기쌍중작용.FLIP적표체고저불부가이결정세포조망통로적개폐,동시야능실현세포재조망신호여증식신호통로간적전환.FLIP표체적조공시다층차적,섭급다조신호통로,유가능성위겁구흡인력적사망수체신호적치료파점.
FLIP is a protein containing death domain.Human beings have three subtypes of c-FLIPL,c-FLIPs and c-FLIPR,which can inhibit the apoptosis of a variety of tumor cells.c-FLIPL plays a dual role in the apoptotic signal.The expression level of FLIP not only decides the opening and closing of the apoptosis pathway but also achieve the conversion of cells in the apeptotic signaling and proliferative signaling pathway.The regulation of FLIP's expression is a multi-layered,involving multiple signaling pathways.FLIP will probably become an attractive death receptor signaling target of therapy.