CAJ | 학술논문

硫氧还蛋白相关蛋白14(TRP14)是一种新发现的硫氧还蛋白(Trx)家族二硫还原酶,具有保守的CPDC模序.其结构和功能既与Trx家族代表性成员Trx具有相似性,又有诸多不同.当肿瘤坏死因子-α(TNF-α)诱导细胞产生活性氧时,TRP14可作为细胞内氧化还原状态的感受器,改变其作用底物动力蛋白轻链的氧化状态,从而调控TNF-α诱导的转录核因子-κB (NF-κB)信号途径、丝裂原活化的蛋白激酶信号途径和凋亡信号途径.
류양환단백상관단백14(TRP14)시일충신발현적류양환단백(Trx)가족이류환원매,구유보수적CPDC모서.기결구화공능기여Trx가족대표성성원Trx구유상사성,우유제다불동.당종류배사인자-α(TNF-α)유도세포산생활성양시,TRP14가작위세포내양화환원상태적감수기,개변기작용저물동력단백경련적양화상태,종이조공TNF-α유도적전록핵인자-κB (NF-κB)신호도경、사렬원활화적단백격매신호도경화조망신호도경.
Thioredoxin-related protein 14 (TRP14),a new member of Trx family,is a novel disulfide reductase with conservative CPDC motif.Its structure and function are comparable to Trx,which is the representative member of Trx family.However,there are many differences.When tumor necrosis factor-α (TNF-α) induced cells to produce the active oxygen,TRP14 can change oxidatin state of dynein light chain(its substrate),act as a sensor of the intracellular redox state to regulate NF-κB signaling pathways induced by TNF-α,MAPK and apoptosis signaling pathways.