CAJ | 학술논문

诱导性多能干细胞(iPSC)是由分化成熟的体细胞在体外重编程获得的.它具有与胚胎干细胞(ESC)相似的无限自我更新能力和多向分化潜能,但不受免疫学和伦理学的约束且获取方便.患者特异性的iPSC是肿瘤治疗中建立疾病模型、药物研发、再生治疗、免疫治疗、细胞载体等的宝贵来源.目前,应用iPSC技术治疗肿瘤已取得一定进展.
유도성다능간세포(iPSC)시유분화성숙적체세포재체외중편정획득적.타구유여배태간세포(ESC)상사적무한자아경신능력화다향분화잠능,단불수면역학화윤리학적약속차획취방편.환자특이성적iPSC시종류치료중건립질병모형、약물연발、재생치료、면역치료、세포재체등적보귀래원.목전,응용iPSC기술치료종류이취득일정진전.
Induced pluripotent stem cells (iPSCs) are derived from differentiated somatic cells through reprogramming in vitro.Similarly to embryonic stem cells (ESCs),iPSCs have the ability of unlimited selfrenewal and multiple differentiation potential.But they are without the constraints of immunology and ethics and acquire conveniently.Patient-specific iPSCs provide an invaluable resource for disease modeling,drug discovery,regenerative therapy,immune therapy and cellular delivery vehicle in cancer therapy.Nowadays,the application of iPSCs technology has made some progress in the treatment of tumors.