CAJ | 학술논문

肿瘤过继性细胞免疫治疗(ACI)是通过调动机体免疫功能以达到消除和控制肿瘤的目的,具有靶向疗效明显、不良反应轻微等优点.细胞因子诱导的杀伤细胞和肿瘤浸润淋巴细胞已广泛用于临床并取得初步疗效.随着特异性转基因T细胞的发展及临床应用,免疫治疗的疗效将进一步增加.目前,改善细胞培养方法、增强细胞本身功能以及联合其他治疗是进一步提高ACI疗效的关键.
종류과계성세포면역치료(ACI)시통과조동궤체면역공능이체도소제화공제종류적목적,구유파향료효명현、불량반응경미등우점.세포인자유도적살상세포화종류침윤림파세포이엄범용우림상병취득초보료효.수착특이성전기인T세포적발전급림상응용,면역치료적료효장진일보증가.목전,개선세포배양방법、증강세포본신공능이급연합기타치료시진일보제고ACI료효적관건.
Adoptive cellular immunotherapy (ACI) achieves the elimination and control of tumor by mobilizing the body's immune function.It also has targeted efficacy and mild untoward effects.Cytokineinduced killer cells and tumor-infiltrating lymphocytes have been widely used in clinic and have obtained preliminary efficacy.With the development and clinical application of the specific gene transfer of T cell,it will further increase the efficacy of immunotherapy.At present,improving cell culture technology and cell function and using with other treatment are the key links to improve the efficacy of ACI.