国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2013年
2期
126-130
,共5页
肺肿瘤%核苷酸切除修复通路%多态性,单核苷酸%疾病易感性
肺腫瘤%覈苷痠切除脩複通路%多態性,單覈苷痠%疾病易感性
폐종류%핵감산절제수복통로%다태성,단핵감산%질병역감성
Lung neoplasms%Nucleotide excision repair pathway%Polymorphisms,single nucleotide%Disease susceptibility
核苷酸切除修复(NER)通路是修复DNA损伤的主要途径之一,其中着色性于皮病A型(XPA)基因、核苷酸切除修复交叉互补1(ERCC1)基因和着色性干皮病D型(XPD)基因的单核苷酸多态性(SNP)改变了NER通路中重要酶与蛋白的修复功能,引起DNA损伤修复能力的差异,最终导致个体肺癌易感性不同.
覈苷痠切除脩複(NER)通路是脩複DNA損傷的主要途徑之一,其中著色性于皮病A型(XPA)基因、覈苷痠切除脩複交扠互補1(ERCC1)基因和著色性榦皮病D型(XPD)基因的單覈苷痠多態性(SNP)改變瞭NER通路中重要酶與蛋白的脩複功能,引起DNA損傷脩複能力的差異,最終導緻箇體肺癌易感性不同.
핵감산절제수복(NER)통로시수복DNA손상적주요도경지일,기중착색성우피병A형(XPA)기인、핵감산절제수복교차호보1(ERCC1)기인화착색성간피병D형(XPD)기인적단핵감산다태성(SNP)개변료NER통로중중요매여단백적수복공능,인기DNA손상수복능력적차이,최종도치개체폐암역감성불동.
Nucleotide excision repair (NER) pathway is one of the principal ways of the repair of DNA damage.The single nucleotide polymorphisms (SNP) of its key genes such as xeroderma pigmentosum group A (XPA) gene,excision repair cross complementingl (ERCC1) gene and xeroderma pigmentosum group D (XPD) gene may be associated with differences in the DNA repair capacity and may influence an individual's risk of lung cancer,because the variant genotype in those polymorphisms might destroy or alter repair function.
