CAJ | 학술논문

吲哚胺2,3双加氧酶(IDO)被认为是一种重要的内源性免疫抑制酶.研究证实IDO在肿瘤的发生发展中扮演十分重要的角色,肿瘤细胞不仅自身能表达IDO,而且还吸引树突状细胞(DC)表达IDO,参与肿瘤免疫耐受的形成.信号转导子与转录激活子家族(STAT)是参与树突状细胞中IDO转录调控的主要信号蛋白家族,详细阐明DC中STAT蛋白对IDO表达的调控机制对于肿瘤治疗很有必要,将会帮助我们开发特异性更强、活性更高的IDO特异性抑制剂,并为抗肿瘤靶向治疗提供新的选择.
신타알2,3쌍가양매(IDO)피인위시일충중요적내원성면역억제매.연구증실IDO재종류적발생발전중분연십분중요적각색,종류세포불부자신능표체IDO,이차환흡인수돌상세포(DC)표체IDO,삼여종류면역내수적형성.신호전도자여전록격활자가족(STAT)시삼여수돌상세포중IDO전록조공적주요신호단백가족,상세천명DC중STAT단백대IDO표체적조공궤제대우종류치료흔유필요,장회방조아문개발특이성경강、활성경고적IDO특이성억제제,병위항종류파향치료제공신적선택.
Indoleamine 2,3-dioxygenase (IDO) is known as an endogenous immunosuppressive enzyme which plays a significant role in the process of tumor.IDO is not only found in tumor cells but also detected in dendritic cell (DC) in tumor microenvironment,which participates in the formation of tumor immune tolerance through expressing IDO enzyme.Signal transducer and activator of transcription (STAT) is the main signal protein family which participates in the IDO transcriptional regulation of DC.It is necessary to detail the signaling pathway in regulating IDO expression,which will help us develop high specific and more active IDO inhibitors and provide new options for anti-cancer targeted therapy.