CAJ | 학술논문

Toll样受体(TLR)家族是重要的模式识别受体(PRR),参与固有免疫,调节适应性免疫.TLR表达于免疫细胞及多种恶性肿瘤细胞,识别保守的分子结构,介导炎症、组织损伤及组织修复,在肿瘤的进程中发挥重要作用.对TLR相关信号分子及信号通路的研究结果表明,TLR具有抗肿瘤及促肿瘤双重作用,在肿瘤的预防和治疗方面具有广阔前景.
Toll양수체(TLR)가족시중요적모식식별수체(PRR),삼여고유면역,조절괄응성면역.TLR표체우면역세포급다충악성종류세포,식별보수적분자결구,개도염증、조직손상급조직수복,재종류적진정중발휘중요작용.대TLR상관신호분자급신호통로적연구결과표명,TLR구유항종류급촉종류쌍중작용,재종류적예방화치료방면구유엄활전경.
Toll-like receptor (TLR) is an important pattem recognition receptor (PRR) which partici pates in innate immunity and regulates adaptive immunity.TLR can be expressed in immune cells and malig nant tumors recognize conservative molecular structure,mediate response of inflammation,tissue injury and repair,which plays an important role in the process of tumor.Research results about some molecules and signal pathways of TLR demonstrate that it can act anti or pro-tumor dual functions,which has an extensive prospects in prevention and treatment of tumor.