国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2013年
3期
177-180
,共4页
肿瘤%肿瘤干细胞%微RNAs%上皮间质转化
腫瘤%腫瘤榦細胞%微RNAs%上皮間質轉化
종류%종류간세포%미RNAs%상피간질전화
Neoplasms%Neoplastic stem cells%MicroRNAs%Epithelial-mesenchymal transitions
上皮间质转化(EMT)不仅赋予细胞迁移和侵袭特征,还可使肿瘤细胞获得自我更新能力而具有干细胞的特性,从而促进肿瘤干细胞(CSC)的产生.EMT与CSC有相通的分子机制及微环境,这对侵袭性肿瘤的诊治具有重大临床意义.另外,微小RNA (miR)-200可调控EMT及CSC,参与肿瘤的侵袭和转移,促进肿瘤靶向治疗的研究.
上皮間質轉化(EMT)不僅賦予細胞遷移和侵襲特徵,還可使腫瘤細胞穫得自我更新能力而具有榦細胞的特性,從而促進腫瘤榦細胞(CSC)的產生.EMT與CSC有相通的分子機製及微環境,這對侵襲性腫瘤的診治具有重大臨床意義.另外,微小RNA (miR)-200可調控EMT及CSC,參與腫瘤的侵襲和轉移,促進腫瘤靶嚮治療的研究.
상피간질전화(EMT)불부부여세포천이화침습특정,환가사종류세포획득자아경신능력이구유간세포적특성,종이촉진종류간세포(CSC)적산생.EMT여CSC유상통적분자궤제급미배경,저대침습성종류적진치구유중대림상의의.령외,미소RNA (miR)-200가조공EMT급CSC,삼여종류적침습화전이,촉진종류파향치료적연구.
Epithelial-mesenchymal transition (EMT) not only can endow cells migration and invasion characteristics,but also can make tumor cells obtain self-renewal ability and have the characteristics of stem cells,which might result in cancer stem cell (CSCs).There are the same molecular mechanism and microenvironment between EMT and CSCs,which have great clinic significances for the diagnosis and treatment of the aggressive cancers.Moreover,many studies show that miR-200 could regulate EMT and CSC,participate in the tumor invasion and metastasi,and promote the research of targeted cancer therapy.
