CAJ | 학술논문

Bmi-1基因作为一种转录抑制因子,是多梳基因(PcG)家族成员之一.可能在于细胞的自我更新与增殖活性起重要作用.目前发现Bmi-1基因在多种实体肿瘤中存在高表达,可看做为肿瘤干细胞标志物之一,并与肿瘤的发生发展及放射抵抗有密切关系,可为恶性肿瘤的治疗提供重要的靶基因.
Bmi-1기인작위일충전록억제인자,시다소기인(PcG)가족성원지일.가능재우세포적자아경신여증식활성기중요작용.목전발현Bmi-1기인재다충실체종류중존재고표체,가간주위종류간세포표지물지일,병여종류적발생발전급방사저항유밀절관계,가위악성종류적치료제공중요적파기인.
As a transcriptional repressor,Bmi-1 is a member of polyeomb group gene family.It may play an important role in self-renewal ability and proliferation of stem cell.At present,studies show that Bmi-1 is highly expressed in a variety of solid tumors,which can be regarded as one of the markers of cancer stem cells and has a close relation to the cancer development and progression and radiation resistance.It will provide an important target gene for the treatment of malignant tumors.