CAJ | 학술논문

肺癌的易感性存在个体差异,参与解毒及生物转化的代谢酶的基因多态性被认为与肺癌易感性相关.催化致癌物质代谢过程的酶主要有Ⅰ相代谢酶和Ⅱ相代谢酶,包括细胞色素P450酶系及由N-乙酰转移酶、微粒体环氧化物酶、醌氧化还原酶1(NQO1)等构成的Ⅱ相代谢酶系,均为预测肺癌易感的候选基因.通过研究代谢酶基因多态性与肺癌易感性的关系,发现有意义的肺癌标志物,筛选肺癌易感人群并提前进行干预,有利于降低肺癌的发病风险.
폐암적역감성존재개체차이,삼여해독급생물전화적대사매적기인다태성피인위여폐암역감성상관.최화치암물질대사과정적매주요유Ⅰ상대사매화Ⅱ상대사매,포괄세포색소P450매계급유N-을선전이매、미립체배양화물매、곤양화환원매1(NQO1)등구성적Ⅱ상대사매계,균위예측폐암역감적후선기인.통과연구대사매기인다태성여폐암역감성적관계,발현유의의적폐암표지물,사선폐암역감인군병제전진행간예,유리우강저폐암적발병풍험.
It is proved that there are significant differences in individual susceptibility to lung cancer.Genetic polymorphisms of several enzymes involved in the detoxification and biotransformation might be related to the lung cancer susceptibility.Cytochromes P450,N-acetyltransferases,microsomal epoxide hydrolase,NQO1 are the most frequently investigated genes in recent years.All theses genes appear to be the candidates for lung cancer susceptibility genes.The studies of the relationship between polymorphisms of metabolic enzymes and lung cancer susceptibility will help to find useful biomarkers.An improved understanding of genetic polymorphisms may help to identify individuals who are at increased risk for lung cancer and decrease the incidence of lung cancer.