CAJ | 학술논문

微小RNA(miRNA)是在真核生物中发现的一类内源性的具有调控功能的非编码RNA,其大小长约20 ～ 25个核苷酸.最新研究发现,miRNA与鼻咽癌中Epstein-Barr病毒(EBV)、潜在的膜蛋白-1(LMP-1)、信号转导通路、肿瘤相关基因网络、细胞有丝分裂、肿瘤血管生成和侵袭转移密切相关.探索miRNA与鼻咽癌发生发展之间的关系,有助于加深对其发病机制的认识,也将为临床诊断和治疗提供新的启示与依据.
미소RNA(miRNA)시재진핵생물중발현적일류내원성적구유조공공능적비편마RNA,기대소장약20 ～ 25개핵감산.최신연구발현,miRNA여비인암중Epstein-Barr병독(EBV)、잠재적막단백-1(LMP-1)、신호전도통로、종류상관기인망락、세포유사분렬、종류혈관생성화침습전이밀절상관.탐색miRNA여비인암발생발전지간적관계,유조우가심대기발병궤제적인식,야장위림상진단화치료제공신적계시여의거.
MicroRNA (miRNA) is a class of endogenous non-coding RNA which found in eukaryotes and has regulatory function.Its size is about 20 to 25 nucleotides.Recent studies found that miRNA is closly related to the EBV,LMP1,signal transduction pathway,tumor-associated gene network,cell mitosis,tumor angiogenesis,tumor invasion and metastasis of nasopharyngeal.Therefore,studing the relationship between miRNA and nasopharyngeal will help to deepen the understanding of its pathogenesis,and also will provide new inspiration and basis for clinical diagnosis and treatment.