国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2013年
5期
362-365
,共4页
血小板因子4%受体,趋化因子%受体,CXCR3%结直肠肿瘤
血小闆因子4%受體,趨化因子%受體,CXCR3%結直腸腫瘤
혈소판인자4%수체,추화인자%수체,CXCR3%결직장종류
Platelet factor 4%Receptors,chemokine%Receptors,CXCR3%Colorectal neoplasms
CXC趋化因子配体4(CXCL4)是一类血小板衍生的趋化因子,属于CXC亚家族.CXCL4的受体CXC趋化因子受体3(CXCR3)为七次跨膜的G蛋白耦联受体,其辅助受体为糖胺聚糖.CXCL4及其受体参与调控体内许多生物学过程,如免疫调节、炎症反应、内皮细胞增殖迁移及血管新生等.近年来研究表明,CXCL4及其受体对结直肠肿瘤的细胞生长、血管生成、浸润和转移等过程有显著影响.这为探讨结直肠肿瘤的发生机制及靶向治疗提供了新视角.
CXC趨化因子配體4(CXCL4)是一類血小闆衍生的趨化因子,屬于CXC亞傢族.CXCL4的受體CXC趨化因子受體3(CXCR3)為七次跨膜的G蛋白耦聯受體,其輔助受體為糖胺聚糖.CXCL4及其受體參與調控體內許多生物學過程,如免疫調節、炎癥反應、內皮細胞增殖遷移及血管新生等.近年來研究錶明,CXCL4及其受體對結直腸腫瘤的細胞生長、血管生成、浸潤和轉移等過程有顯著影響.這為探討結直腸腫瘤的髮生機製及靶嚮治療提供瞭新視角.
CXC추화인자배체4(CXCL4)시일류혈소판연생적추화인자,속우CXC아가족.CXCL4적수체CXC추화인자수체3(CXCR3)위칠차과막적G단백우련수체,기보조수체위당알취당.CXCL4급기수체삼여조공체내허다생물학과정,여면역조절、염증반응、내피세포증식천이급혈관신생등.근년래연구표명,CXCL4급기수체대결직장종류적세포생장、혈관생성、침윤화전이등과정유현저영향.저위탐토결직장종류적발생궤제급파향치료제공료신시각.
CXC chemokine ligand 4 (CXCL4) is a platelet-derived chemokine,and it belongs to CXC subfamily.Its receptor is CXC chemokine receptor 3 (CXCR3),which belongs to the seven transmebrane G-protein-coupled receptor family,and its coreceptor is glycosaminoglycan (GAG).CXCL4 and its receptors take part in the regulation of many biological processes,such as immune regulation,inflammatory response,endothelial cell proliferation and migration and angiogenesis.Recent studies show that CXCL4 and its receptor have significant influence on the cell growth,angiogenesis,invasion and metastasis of colorectal cancer,which offers a new perspective to explore the mechanism of colorectal cancer and its targeted therapy.
