CAJ | 학술논문

癌基因Pim-1与多种肿瘤的发生发展密切相关,参与多个信号转导通路,调节下游生物因子的表达,或与其他癌基因协同作用,在相关肿瘤的诊断、治疗及预后评估中具有重要作用,同时也提供了新的潜在靶点.目前以Pim-1为靶点,探索治疗肿瘤的新策略成为研究热点,将有望用于肿瘤临床治疗.
암기인Pim-1여다충종류적발생발전밀절상관,삼여다개신호전도통로,조절하유생물인자적표체,혹여기타암기인협동작용,재상관종류적진단、치료급예후평고중구유중요작용,동시야제공료신적잠재파점.목전이Pim-1위파점,탐색치료종류적신책략성위연구열점,장유망용우종류림상치료.
Oncogene Pim-1 has a close relationship with the occurrence and development of several tumours.It is involved in a number of signal transduction pathways and regulates the expression of the downstream biological factors or acts synergistically with other oncogenes.Pim-1 plays an important role in the clinical diagnosis,treatment and prognosis of some tumors,and provides a new potential target in the chemotherapy of tumors.Recently,Pim-1-targeting treatment strategy has be a research hotspot and it would be used for cancer clinical treatment hopefully.