CAJ | 학술논문

微小RNA (miR)-203具有细胞干性抑制潜能,可通过抑制细胞干性相关转录因子的表达来调节细胞上皮样分化.研究表明miR-203在多种肿瘤组织中表达异常,包括膀胱癌、乳腺癌、结肠癌和胰腺癌等.miR-203通过调节细胞增殖、分化和凋亡在肿瘤的发生发展中发挥重要作用.
미소RNA (miR)-203구유세포간성억제잠능,가통과억제세포간성상관전록인자적표체래조절세포상피양분화.연구표명miR-203재다충종류조직중표체이상,포괄방광암、유선암、결장암화이선암등.miR-203통과조절세포증식、분화화조망재종류적발생발전중발휘중요작용.
MicroRNA(miR)-203 is a stemness-inhibiting miRNA that adjusts the epithelioid cell differentiation by restricting the expression of stemness-related transcription factor.Its abnormal expression has been detected in several types of human cancers,including bladder cancer,breast cancer,colon cancer and pancreatic cancer.miR-203 plays a critical role in the tumor genesis and development by regulating cell proliferation,differentiation and apoptosis.