国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2013年
6期
428-431
,共4页
免疫抑制法%炎症%肿瘤%T淋巴细胞,调节性%髓源性抑制细胞
免疫抑製法%炎癥%腫瘤%T淋巴細胞,調節性%髓源性抑製細胞
면역억제법%염증%종류%T림파세포,조절성%수원성억제세포
Immunosuppression%Inflammation%Neoplasms%T-lymphocytes,regulator%Myeloidderived suppressor cells
髓源性抑制细胞(MDSC)和调节性T细胞(Treg)是重要的抑制性免疫细胞,在炎症、感染和肿瘤中大量扩增,可通过多种机制抑制机体抗肿瘤免疫,促进肿瘤生长和转移.寻找肿瘤微环境中MDSC、Treg细胞升高的原因及清除方法,已成为肿瘤免疫治疗的研究热点.
髓源性抑製細胞(MDSC)和調節性T細胞(Treg)是重要的抑製性免疫細胞,在炎癥、感染和腫瘤中大量擴增,可通過多種機製抑製機體抗腫瘤免疫,促進腫瘤生長和轉移.尋找腫瘤微環境中MDSC、Treg細胞升高的原因及清除方法,已成為腫瘤免疫治療的研究熱點.
수원성억제세포(MDSC)화조절성T세포(Treg)시중요적억제성면역세포,재염증、감염화종류중대량확증,가통과다충궤제억제궤체항종류면역,촉진종류생장화전이.심조종류미배경중MDSC、Treg세포승고적원인급청제방법,이성위종류면역치료적연구열점.
Myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs) are important inhibitory immune cells.Research finds that MDSCs and Tregs increase in a large number under the conditions of inflammation,infection and tumor and they are able to suppress the immunity system and promote tumorigenesis and metastasis through multiple mechanisms.Finding the causes resulting in the increase of MDSCs and Tregs in tumor microenvironment and the eliminating methods have become new focuses in the field of antitumor immunotherapy.
