CAJ | 학술논문

肺癌的发生发展与众多肺癌相关基因的表达及突变有密切关系.近期国内外肺癌的相关基因研究显示,COPS3基因的表达在刺激肺癌细胞增殖的过程中可能发挥关键作用,棘皮动物微管样蛋白4-间变淋巴瘤激酶融合基因与表皮生长因子受体突变共存,GA733基因与肺癌的生存期密切相关.同时成纤维细胞生长因子受体1、高迁移率蛋白家族、类清道夫受体成员5和表皮生长因子受体为肺癌的基因靶向治疗提供了新思路.肺癌的治疗需要多基因联合治疗和基因治疗联合常规治疗.
폐암적발생발전여음다폐암상관기인적표체급돌변유밀절관계.근기국내외폐암적상관기인연구현시,COPS3기인적표체재자격폐암세포증식적과정중가능발휘관건작용,극피동물미관양단백4-간변림파류격매융합기인여표피생장인자수체돌변공존,GA733기인여폐암적생존기밀절상관.동시성섬유세포생장인자수체1、고천이솔단백가족、류청도부수체성원5화표피생장인자수체위폐암적기인파향치료제공료신사로.폐암적치료수요다기인연합치료화기인치료연합상규치료.
The occurrence and development of lung cancer are closely related to gene expression and mutations.Recent studies of lung cancer related genes show that the expression of COPS3 gene may play a key role in the lung cancer cell proliferation.Echinoderm microtubule associated protein like 4-anaplastic lymphoma kinase fusion gene and epidermal growth factor receptor mutations coexist.GA733 gene is closely related to lung cancer survival.Fibroblast growth factor receptor 1,high mobility protein family,members of the scavenger receptor class 5 and epidermal growth factor receptor provide new ideas for targeted therapy of lung cancer.For the therapy of lung cancer,multiple gene therapy and gene therapy combined with conventional treatment is required.