CAJ | 학술논문

过氧化物酶体增殖物激活受体(PPAR)γ是一类配体激活的核转录因子,属于核受体超家族成员,在调节糖和脂肪代谢,肿瘤细胞增殖、分化、凋亡、侵袭和远处转移等方面发挥重要作用.研究显示在人类肺癌组织和多种肺癌细胞株中均有PPARγ表达,且经其配体活化后能显著地干预包括肺癌在内的多种癌的进展和演变.但近来也有资料表明激活PPARγ导致促癌效应.
과양화물매체증식물격활수체(PPAR)γ시일류배체격활적핵전록인자,속우핵수체초가족성원,재조절당화지방대사,종류세포증식、분화、조망、침습화원처전이등방면발휘중요작용.연구현시재인류폐암조직화다충폐암세포주중균유PPARγ표체,차경기배체활화후능현저지간예포괄폐암재내적다충암적진전화연변.단근래야유자료표명격활PPARγ도치촉암효응.
Peroxisome proliferator activated receptor-γ (PPARγ) is a member of the nuclear receptor superfamily of ligand-activated transcription factors that plays a critical role in regulating glucose and lipid homeostasis,and in the processes of tumor cell proliferation,differentiation,apoptosis,invasion and distant metastasis.Studies demonstrate that PPARγexpression is detected in human lung cancer tissues and numerous lung cancer cell lines.Activation of PPARγthrough its ligands impedes significantly a variety of tumor progression,including lung cancer.However,systemic activation of PPARγhas been reported to be protumorigenic in some in vitro systems and in vivo models.