CAJ | 학술논문

髓系来源抑制性细胞(MDSC)是一群来源于髓系的异质性未分化成熟的细胞；在感染、创伤、败血症,尤其是肿瘤等病理状态下,MDSC在血液、淋巴器官、脾脏及肿瘤等组织中大量聚集；MDSC可以通过多种机制抑制肿瘤免疫,MDSC在患者外周血的数量与肿瘤的分期、负荷、远处转移及患者的预后密切相关.然而关于MDSC的研究结果大部分来自小鼠实验,由于肿瘤患者MDSC的表型比较复杂,其研究进展相对缓慢.
수계래원억제성세포(MDSC)시일군래원우수계적이질성미분화성숙적세포；재감염、창상、패혈증,우기시종류등병리상태하,MDSC재혈액、림파기관、비장급종류등조직중대량취집；MDSC가이통과다충궤제억제종류면역,MDSC재환자외주혈적수량여종류적분기、부하、원처전이급환자적예후밀절상관.연이관우MDSC적연구결과대부분래자소서실험,유우종류환자MDSC적표형비교복잡,기연구진전상대완만.
Myeloid-derived suppressor cells (MDSCs) are a group of heterogeneous and immature myeloid-derived cells,which accumulate largely in blood,lymphoid organs,spleen and tumor tissue and so on under the different pathogenic conditions such as infection,trauma,hematosepsis,especially tumor and so on.MDSCs can suppress tumor immune through many mechanisms.The number of MDSCs in periphery blood of patients is closely related with tumor stage,tumor burden,remote metastasis and prognosis.The major results are from laboratory mice.Because of the complexity of MDSCs in patients with tumor,there are many difficulties and debate on the research of them,and the researches of human MDSCs progress slowly.