CAJ | 학술논문

侵袭和转移是造成肝细胞肝癌(HCC)预后不良的重要因素.近年来,HCC上皮间质转化(EMT)已经被认为是HCC侵袭、转移的关键细胞学基础.尽管引起和维持EMT的分子机制并没有被完全阐明,但是转化生长因子-β (TGF-β)、磷脂酰肌醇3激酶(PI3K)/蛋白激酶B(AKT)、细胞核转录因子-κB (NF-κB)、Wnt/β-连接素(β-catenin)等细胞信号通路在EMT过程中的所起到的重要作用已经被证实.上述通路通过调控EMT过程直接或间接影响HCC的预后,这也为HCC的新型靶向药物的研究提供了分子基础.
침습화전이시조성간세포간암(HCC)예후불량적중요인소.근년래,HCC상피간질전화(EMT)이경피인위시HCC침습、전이적관건세포학기출.진관인기화유지EMT적분자궤제병몰유피완전천명,단시전화생장인자-β (TGF-β)、린지선기순3격매(PI3K)/단백격매B(AKT)、세포핵전록인자-κB (NF-κB)、Wnt/β-련접소(β-catenin)등세포신호통로재EMT과정중적소기도적중요작용이경피증실.상술통로통과조공EMT과정직접혹간접영향HCC적예후,저야위HCC적신형파향약물적연구제공료분자기출.
The poor prognosis of hepatocellular carcinoma (HCC) is strongly associated with invasion and metastasis.Recently,the epithelial-mesenchymal transition (EMT) has been confirmed to be the cytological foundation of invasion and metastasis.Yet,the molecular mechanism of inducing and maintaining EMT has not been expounded completely.However,it has been demonstrated that transforming growth factor-β (TGF-β),phosphatidyl inositol 3-kinase/protein kinase B (PI3K/AKT),nuclear factor-κB (NF-κB),Wnt/β-catenin signaling pathways play pivotal roles in the initiation and development of EMT.These signaling pathways can affect the prognosis of HCC by regulating EMT.From a drug development perspective,these signal pathways are potential and attractive targets for HCC treatment.