CAJ | 학술논문

Notch信号转导通路参与调控细胞增生、分化及凋亡.异常的Notch信号转导通路可以诱导转基因鼠乳腺癌的发生,而在乳腺癌患者中,高表达Notch受体和(或)配体则与预后不良相关,因此靶向抑制Notch信号转导通路可能对乳腺癌治疗有益.
Notch신호전도통로삼여조공세포증생、분화급조망.이상적Notch신호전도통로가이유도전기인서유선암적발생,이재유선암환자중,고표체Notch수체화(혹)배체칙여예후불량상관,인차파향억제Notch신호전도통로가능대유선암치료유익.
Studies show that the Notch signal transduction pathway involves in the regulation and control of cell proliferation,differentiation and apoptosis.Aberrant Notch signaling transduction pathway can induce breast cancer in transgenic mice.High expressions of either Notch receptors or their ligands have been linked to poor prognosis in patients with breast cancer.Inhibition of Notch signal transduction pathway may be beneficial for breast cancer treatment.