CAJ | 학술논문

G蛋白调节信号5(RGS5)是G蛋白信号调节蛋白(RGS)家族中的一员,负性调节该信号通路的传导.RGS5主要表达在血管周细胞,与血管的发生、发展及成熟密切相关.RGS5基因缺失可引起周细胞成熟和肿瘤血管正常化,此期间联合化疗或免疫治疗可提高疗效,提示RGS5可能成为抗肿瘤治疗的新靶点.RGS5还与肿瘤转移、细胞凋亡有关,可通过诱导细胞凋亡来增加抗肿瘤治疗的效果.
G단백조절신호5(RGS5)시G단백신호조절단백(RGS)가족중적일원,부성조절해신호통로적전도.RGS5주요표체재혈관주세포,여혈관적발생、발전급성숙밀절상관.RGS5기인결실가인기주세포성숙화종류혈관정상화,차기간연합화료혹면역치료가제고료효,제시RGS5가능성위항종류치료적신파점.RGS5환여종류전이、세포조망유관,가통과유도세포조망래증가항종류치료적효과.
Regulator of G-protein signaling 5 (RGS5) belongs to RGS family,which can negatively regulate the conduction of this signaling pathway.RGS5 mainly expresses in vascular pericyte,and is closely related to the occurrence,development and maturation of the blood vessels.Loss of RGS5 results in pericyte maturation,tumor vascular normalization,and these changes can improve the curative effect combined with chemotherapy and immunotherapy,indicating that RGS5 may become a new target of anti-tumor treatment.In addition,RGS5 involves in tumor metastasis and apoptosis,which can improve antineoplastic effect by inducing tumor cells apoptosis.