国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2013年
10期
732-735
,共4页
烟酰胺N-甲基转移酶%烟酰胺%肿瘤
煙酰胺N-甲基轉移酶%煙酰胺%腫瘤
연선알N-갑기전이매%연선알%종류
Nicotinamide N-methyltransferase%Nicotinamide%Neoplasms
烟酰胺N-甲基转移酶(NNMT)是一种S-腺苷-L蛋氨酸(SAM)依赖性胞质酶,在多种药物和异型生物质的生物转化和解毒中起重要作用.近年来研究发现,NNMT在多种肿瘤中异常表达,可能与肿瘤的发生、发展以及放化疗抵抗密切相关.
煙酰胺N-甲基轉移酶(NNMT)是一種S-腺苷-L蛋氨痠(SAM)依賴性胞質酶,在多種藥物和異型生物質的生物轉化和解毒中起重要作用.近年來研究髮現,NNMT在多種腫瘤中異常錶達,可能與腫瘤的髮生、髮展以及放化療牴抗密切相關.
연선알N-갑기전이매(NNMT)시일충S-선감-L단안산(SAM)의뢰성포질매,재다충약물화이형생물질적생물전화화해독중기중요작용.근년래연구발현,NNMT재다충종류중이상표체,가능여종류적발생、발전이급방화료저항밀절상관.
Nicotinamide N-methyltransferase (NNMT) is a S-adenosyl-L-methionine (SAM) dependent cytoplasm enzyme,which plays a vital role in the biotransformation and detoxification of many drugs and xenobiotic compounds.Recent studies have revealed abnormal expression of NNMT in many tumors,which may contribute to tumorigenesis and tumor development and radiotherapy or chemotherapy resistance.
