减毒沙门菌在肿瘤基因治疗中的应用
감독사문균재종류기인치료중적응용
Application of attenuated salmonella in the gene treatment of tumor
  • 万方数据
    国际肿瘤学杂志 국제종류학잡지
    JOURNAL OF INTERNATIONAL ONCOLOGY
    2013年 10期 748-751 ,共4页

    李鹏飞%孙君重

    리붕비%손군중

    减毒沙门菌%肿瘤%疫苗载体%损伤修复 減毒沙門菌%腫瘤%疫苗載體%損傷脩複
    감독사문균%종류%역묘재체%손상수복
    Attenuated salmonella%Neoplasms%Vaccine carrier%Damage repairment
    沙门菌是一类胞内侵袭性兼性厌氧菌,减毒后仍保留其抗原性,现在广泛作为DNA疫苗的载体.沙门菌携带相关抗原基因对多种肿瘤有显著的抑制效果,而且携带修复基因对放化疗后的机体损伤有着明确的修复作用.
    사문균시일류포내침습성겸성염양균,감독후잉보류기항원성,현재엄범작위DNA역묘적재체.사문균휴대상관항원기인대다충종류유현저적억제효과,이차휴대수복기인대방화료후적궤체손상유착명학적수복작용.
    Salmonella is a kind of intracellular invasive facultative anaerobe,maintaining its antigenicity after being attenuated.Now,it has been widely used as a transporter of DNA vaccines.Salmonella carrying related antigen gene can inhibit multiple tumors,and salmonella carrying repair gene has a clear repair effect for the organism injury after chemoradiotherapy.
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