CAJ | 학술논문

在非兴奋型细胞中,钙库调控性钙通道(SOCC)是胞外钙离子进入胞内的最主要途径,可调控多种肿瘤细胞的生物学特性,包括黏附、分泌、运动、基因表达、增殖、分裂与凋亡等.基质交联分子1(STIM1)和Orail是SOCC的重要组成部分,故过表达或抑制表达STIM1/Orail可调控SOCC活性和肿瘤细胞的生物学特性.而SOCC对肿瘤细胞的作用却自相矛盾,既可促进肿瘤进展,又可抑制肿瘤进展.SOCC有望成为治疗肿瘤的一个新靶点,但其机制复杂,既需考虑肿瘤细胞类型,还需考虑外界刺激因子对肿瘤细胞的作用.
재비흥강형세포중,개고조공성개통도(SOCC)시포외개리자진입포내적최주요도경,가조공다충종류세포적생물학특성,포괄점부、분비、운동、기인표체、증식、분렬여조망등.기질교련분자1(STIM1)화Orail시SOCC적중요조성부분,고과표체혹억제표체STIM1/Orail가조공SOCC활성화종류세포적생물학특성.이SOCC대종류세포적작용각자상모순,기가촉진종류진전,우가억제종류진전.SOCC유망성위치료종류적일개신파점,단기궤제복잡,기수고필종류세포류형,환수고필외계자격인자대종류세포적작용.
In most non-excitable cells,the store-operated calcium channel (SOCC) in the plasma membrane is the major calcium entry pathway.SOCC plays an important role in calcium signals that control many cancer cellular processes such as adhesion,secretion,movement,gene expression,proliferation,division and apoptosis.Stromal interaction molecule 1 (STIM1) and Orail are the two important parts of SOCC.So overexpression or suppression expression of STIM1/Orail can regulate SOCC activity and biological characteristics of cancer cells.However,SOCC plays a contradictory role in cancer cells,which can both promote tumor progression and inhibit tumor progression.SOCC is expected to become a new target for the treatment of tumors,but its complicated mechanism needs to consider both types of tumor cells and the external stimulators of tumor cells.