CAJ | 학술논문

CD47是个多能分子,在肿瘤细胞逃避免疫监视过程中扮演重要角色,阻断CD47信号通道能有效激发巨噬细胞对肿瘤细胞的吞噬作用,成为非常有前景的肿瘤免疫治疗新途径.靶向CD47的单克隆抗体已成为近年来研究的新热点,目前的实验进展顺利,有必要进行更详尽的研究,使其早日进入临床应用.
CD47시개다능분자,재종류세포도피면역감시과정중분연중요각색,조단CD47신호통도능유효격발거서세포대종류세포적탄서작용,성위비상유전경적종류면역치료신도경.파향CD47적단극륭항체이성위근년래연구적신열점,목전적실험진전순리,유필요진행경상진적연구,사기조일진입림상응용.
CD47 is a pluripotent molecule which plays a key role in the process of tumor immune escape.Blocking CD47 signal pathway can activate the macrophages to phagocytose tumor cells,which becomes a promising way for tumor immunotherapy.Monoclonal antibodies targeting CD47 have been the new focus during recent years.Present researches are carried out successfully,however it still needs more work before the clinical application of monoclonal antibodies targeting CD47.