CAJ | 학술논문

188铼标记的依替膦酸盐(188Re-HEDP)是亲骨性的二膦酸盐化合物,参与骨盐的代谢,抑制溶骨,并浓聚于肿瘤骨转移灶.近年来研究发现188Re-HEDP具有较好的理化特性和生物特性,对于多种肿瘤骨转移疼痛都有较好的疗效,提示有可能成为肿瘤骨转移的有效治疗方法.
188래표기적의체련산염(188Re-HEDP)시친골성적이련산염화합물,삼여골염적대사,억제용골,병농취우종류골전이조.근년래연구발현188Re-HEDP구유교호적이화특성화생물특성,대우다충종류골전이동통도유교호적료효,제시유가능성위종류골전이적유효치료방법.
188Re-HEDP is a bisphosphonate which preferentially incorporates into the sites of bone metastases.It interacts with bone metabolism,suppresses the activity of osteolysis,and gathers in tumor bone metastases.Recently,researches show that 188Re-HEDP has some advantages for palliation of bone metastasisrelated pain because of its favorable physicochemical and biological characteristics,188Re-HEDP radioisotopes therapy will be an effective method for bone metastatic tumors.