CAJ | 학술논문

在上皮-间质转化(EMT)过程中,细胞间连接被破坏,细胞失去顶-底极性,获得抗凋亡能力及迁移、侵袭能力.Y盒结合蛋白1 (YB-1)是冷休克蛋白超家族的一员,包含结构和功能高度保守的冷休克结构域.研究表明,YB-1可以通过调控EMT促进肿瘤的发生发展.在YB-1介导的EMT中,多种转录因子及信号通路发挥着重要作用.
재상피-간질전화(EMT)과정중,세포간련접피파배,세포실거정-저겁성,획득항조망능력급천이、침습능력.Y합결합단백1 (YB-1)시랭휴극단백초가족적일원,포함결구화공능고도보수적랭휴극결구역.연구표명,YB-1가이통과조공EMT촉진종류적발생발전.재YB-1개도적EMT중,다충전록인자급신호통로발휘착중요작용.
In the process of epithelial-mesenchymal transition (EMT),cell-cell adherence is disrupted,apico-basal polarity is lost,the ability of anti-apoptosis,migration and invasion is acquired.Y-box-binding protein 1 (YB-1) is a member of the cold-shock protein superfamily,containing a structurally and functionally conserved cold shock domain.Studies indicate that YB-1 can promote the occurrence and development of tumors by regulating EMT.In the process of EMT mediated by YB-1,various transcription factors and signal pathways play important roles.