CAJ | 학술논문

let-7家族是重要的肿瘤抑制因子,在干细胞分化和肿瘤抑制中起重要作用.RNA结合蛋白lin28是重要的干细胞因子,能维持细胞干性,促进细胞恶性转化.lin28可与let-7前体结合,阻断let-7成熟；而let-7可结合至lin28 mRNA的3’-非翻译区(UTR),抑制lin28表达.lin28-let-7形成一个双向负反馈环路,参与干细胞分化、肿瘤发生、侵袭转移、耐药复发等生物过程,可作为肿瘤治疗新靶点.
let-7가족시중요적종류억제인자,재간세포분화화종류억제중기중요작용.RNA결합단백lin28시중요적간세포인자,능유지세포간성,촉진세포악성전화.lin28가여let-7전체결합,조단let-7성숙；이let-7가결합지lin28 mRNA적3’-비번역구(UTR),억제lin28표체.lin28-let-7형성일개쌍향부반궤배로,삼여간세포분화、종류발생、침습전이、내약복발등생물과정,가작위종류치료신파점.
The microRNA let-7 family,functioning as a tumor suppressor,has emerged as a regulator of stem cell differentiation and tumor repression.The RNA-binding protein lin28 is a stem cell pluripotency factor,which contributes to the maintenance of stem cell characteristics and promoting cell malignant transformation.lin28 can block the maturity of let-7 by combining with the precursors of let-7 family miRNAs,which is itself able to repress lin28 by binding to the 3'-UTR of lin28 transcripts,thus forming a feedback loop.The double-negative feedback loop comprising lin28 and let-7 is involved in several biological processes such as differentiation of stem cell,tumorigenesis,invasion and metastasis,drug resistance and relapse,which couldbe a potential target for cancer therapy.