CAJ | 학술논문

上皮间质转化(E MT)是上皮细胞向间充质细胞分化的过程,EMT在恶性肿瘤的侵袭转移中广泛存在.EMT的发生与多种细胞因子、信号转导通路及转录因子有关,受多种影响因素的共同调控.上皮细胞表型的不同程度转化是细胞内外信号传递共同作用的结果.细胞外信号通过与细胞表面特异性受体相结合将信号转入细胞内,再通过胞内的信号转导途径,活化不同的核内转导因子,最终调节转导基因的表达.
상피간질전화(E MT)시상피세포향간충질세포분화적과정,EMT재악성종류적침습전이중엄범존재.EMT적발생여다충세포인자、신호전도통로급전록인자유관,수다충영향인소적공동조공.상피세포표형적불동정도전화시세포내외신호전체공동작용적결과.세포외신호통과여세포표면특이성수체상결합장신호전입세포내,재통과포내적신호전도도경,활화불동적핵내전도인자,최종조절전도기인적표체.
Epithelial-mesenchymal transition (EMT) is a differentiation process of epithelial cells into mesenchymals,which is widespread in the invasion and metastasis of malignant tumor.Studies show that EMT is influenced by a variety of factors such as cytokines,signaling pathways and transcription factors.Studies also show that intracellular and extracellular signal transmission could induce EMT.Signal transduction is a process which involves ligand-receptor binding in the extracellular,going into the cell and activating different nuclear transduction factor through intracellular signal transduction pathway.