CAJ | 학술논문

骨改良药是一类缓解因骨转移引起的疼痛、病理性骨折、脊髓压迫、高钙血症等一系列骨相关事件药物的总称.目前主要有双膦酸盐类药物和地诺单抗.骨改良药应用于证实有骨质破坏的骨转移患者,作为化疗、放疗的辅助用药,可以明显提高疗效,延长患者的生存期.此外,中医中药也可以有效缓解骨转移引起的一系列相关症状,改善预后.临床工作中要选择合理的药物,才能最大限度地降低骨转移患者的痛苦,提高生活质量.
골개량약시일류완해인골전이인기적동통、병이성골절、척수압박、고개혈증등일계렬골상관사건약물적총칭.목전주요유쌍련산염류약물화지낙단항.골개량약응용우증실유골질파배적골전이환자,작위화료、방료적보조용약,가이명현제고료효,연장환자적생존기.차외,중의중약야가이유효완해골전이인기적일계렬상관증상,개선예후.림상공작중요선택합리적약물,재능최대한도지강저골전이환자적통고,제고생활질량.
Bone-modifying agents (BMA) is a series drugs to alleviate the pain,pathological fractures,spinal cord compression,hypercalcemia,bone-related events which induced by bone metastases.Bisphosphonate drugs and denosumab are two dominant kinds of BMA at present.It has been proved that BMA is used in bone metastases patients with bone destruction,as adjuvant therapy for chemotherapy and radiotherapy,which can significantly improve the efficacy and prolong the survival of patients.In addition,some traditional Chinese medcine can effectively relieve a series of related symptoms caused by bone metastases and improve prognosis.Choosing right medication in clinical work can maximize the reduction of pain caused by bonerelated events and improve the quality of life of patients.