国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2014年
3期
229-232
,共4页
姜丽%赵文明%孙吉瑞%周炳娟%张金库
薑麗%趙文明%孫吉瑞%週炳娟%張金庫
강려%조문명%손길서%주병연%장금고
S100蛋白质类%癌,基底细胞%乳腺肿瘤%新生血管化,病理性
S100蛋白質類%癌,基底細胞%乳腺腫瘤%新生血管化,病理性
S100단백질류%암,기저세포%유선종류%신생혈관화,병이성
S100 proteins%Carcinoma,basal cell%Breast neoplasms%Neovascularization,pathologic
目的 检测S100A7蛋白和CD34蛋白在基底细胞样乳腺癌中的表达情况,分析S100A7与基底细胞样乳腺癌临床病理特征之间的关系及其与CD34标记的微血管密度(MVD)值之间的关系,探讨S100A7在基底细胞样乳腺癌血管生成和侵袭转移中的作用.方法 采用免疫组织化学二步法检测60例基底细胞样乳腺癌、40例非基底细胞样乳腺癌、20例正常乳腺组织中S100A7和CD34的表达情况.结果 S100A7在基底细胞样乳腺癌、非基底细胞样乳腺癌及正常乳腺组织中的表达率分别为83.33％、62.50％、35.00％,差异有统计学意义(x2=5.556,P＜0.05;x2=17.107,P＜0.05; x2 =4.051,P＜0.05).S100A7与基底细胞样乳腺癌患者的淋巴结转移、TNM分期及MVD值呈正相关,而与患者的年龄、肿瘤大小无明显相关性.结论 S100A7的表达上调可能与基底细胞样乳腺癌的发生发展、侵袭转移及血管形成过程有关.S100A7促进血管的生成的作用可能是其促进肿瘤的局部侵袭和远处转移的重要因素.
目的 檢測S100A7蛋白和CD34蛋白在基底細胞樣乳腺癌中的錶達情況,分析S100A7與基底細胞樣乳腺癌臨床病理特徵之間的關繫及其與CD34標記的微血管密度(MVD)值之間的關繫,探討S100A7在基底細胞樣乳腺癌血管生成和侵襲轉移中的作用.方法 採用免疫組織化學二步法檢測60例基底細胞樣乳腺癌、40例非基底細胞樣乳腺癌、20例正常乳腺組織中S100A7和CD34的錶達情況.結果 S100A7在基底細胞樣乳腺癌、非基底細胞樣乳腺癌及正常乳腺組織中的錶達率分彆為83.33％、62.50％、35.00％,差異有統計學意義(x2=5.556,P＜0.05;x2=17.107,P＜0.05; x2 =4.051,P＜0.05).S100A7與基底細胞樣乳腺癌患者的淋巴結轉移、TNM分期及MVD值呈正相關,而與患者的年齡、腫瘤大小無明顯相關性.結論 S100A7的錶達上調可能與基底細胞樣乳腺癌的髮生髮展、侵襲轉移及血管形成過程有關.S100A7促進血管的生成的作用可能是其促進腫瘤的跼部侵襲和遠處轉移的重要因素.
목적 검측S100A7단백화CD34단백재기저세포양유선암중적표체정황,분석S100A7여기저세포양유선암림상병리특정지간적관계급기여CD34표기적미혈관밀도(MVD)치지간적관계,탐토S100A7재기저세포양유선암혈관생성화침습전이중적작용.방법 채용면역조직화학이보법검측60례기저세포양유선암、40례비기저세포양유선암、20례정상유선조직중S100A7화CD34적표체정황.결과 S100A7재기저세포양유선암、비기저세포양유선암급정상유선조직중적표체솔분별위83.33％、62.50％、35.00％,차이유통계학의의(x2=5.556,P＜0.05;x2=17.107,P＜0.05; x2 =4.051,P＜0.05).S100A7여기저세포양유선암환자적림파결전이、TNM분기급MVD치정정상관,이여환자적년령、종류대소무명현상관성.결론 S100A7적표체상조가능여기저세포양유선암적발생발전、침습전이급혈관형성과정유관.S100A7촉진혈관적생성적작용가능시기촉진종류적국부침습화원처전이적중요인소.
Objective To detect the protein expressions of S100A7 and CD34 in basal-like breast carcinoma and analyze the clinical relationship between S100A7 and basal-like breast cancer and the connection with CD34 markers microvessel denisity (MVD).To study the function of S100A7 in basal-like breast cancer angiogenesis,invasion and metastasis.Methods Immunohistochemistry (IHC) was used to detect the expressions of S100A7 and CD34 in 60 cases of basal-like breast cancer,40 cases of non basal-like breast cancer and 20 cases of normal breast tissues.Results The expressions of S100A7 in basal-like breast cancer,non basallike breast cancer and normal breast tissues were 83.33％,62.50％ and 35.00％ respectively.There were significant differences among them (x2 =5.556,P ＜ 0.051; x2 =17.107,P ＜ 0.05; x2 =4.051,P ＜ 0.05).There was positive correlation between S100A7 and lymph node metastasis,TNM staging and MVD of basal-like breast cancer patients.But there was no significant correlation between S100A7 and patient's age and tumor sizes.Conclusion The up-regulation of S100A7 expressions may be associated with the occurrence and development,invasion and metastasis,angiogenesis of basal-like breast cancer.The effects of S100A7 promoting angiogenesis may be an important factor in the acceleration of the local invasion and distant metastasis in basallike breast cancer.
