CAJ | 학술논문

早期研究一致认为细胞间隙连接蛋白(connexin)基因是抑癌基因,在乳腺癌中起抑制肿瘤发生发展的作用,但近年研究发现在很多转移性乳腺癌中connexin表达反而升高,connexin基因可能促进乳腺癌的远处转移.故推测在乳腺癌发生发展、侵袭转移中,connexin通过多种作用机制扮演了不同的角色.在乳腺癌治疗中合理应用connexin将改善患者的疗效.
조기연구일치인위세포간극련접단백(connexin)기인시억암기인,재유선암중기억제종류발생발전적작용,단근년연구발현재흔다전이성유선암중connexin표체반이승고,connexin기인가능촉진유선암적원처전이.고추측재유선암발생발전、침습전이중,connexin통과다충작용궤제분연료불동적각색.재유선암치료중합리응용connexin장개선환자적료효.
The previous studies identify connexin as a tumor suppressor gene,which inhibits the occurrence and development of breast cancer.However,some researches of resent years demonstrate that the expression level of connexin in a large part of metastatic breast cancer is elevated and connexin may promote breast cancer metastasis.Therefore,connexin may play different roles by different mechanisms in the occurrence,development,invasion and metastasis of breast cancer.Rational use of connexin in breast cancer treatment can be beneficial to breast cancer patients.