CAJ | 학술논문

研究表明,肿瘤相关基因启动子区域的异常甲基化是引发肾癌的重要原因之一,并与肿瘤的分化、侵袭、转移、分期和预后等密切相关.检测相关抑癌基因甲基化有助于肾癌的早期诊断.甲基转移酶抑制剂可逆转肿瘤细胞的异常甲基化,并可增加其他化疗药物的疗效,在肾癌的治疗中起重要作用.
연구표명,종류상관기인계동자구역적이상갑기화시인발신암적중요원인지일,병여종류적분화、침습、전이、분기화예후등밀절상관.검측상관억암기인갑기화유조우신암적조기진단.갑기전이매억제제가역전종류세포적이상갑기화,병가증가기타화료약물적료효,재신암적치료중기중요작용.
Researches show that the tumor related gene promoter methylation is an important reason of renal cancer and is closely associated with the differentiation,invasion,metastasis,staging and prognosis of tumor.Methylation detection of related tumor suppressor genes is helpful in early diagnosis of renal cancer.Methyltransferase inhibitors can reverse abnormal methylation of tumor cells,increase the curative effect of other chemotherapy drugs and play an important role in the treatment of renal cancer.