国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2014年
4期
309-314
,共6页
邓成辉%关泉林%姜雷%李小奇%甘亮亮%魏孔孔
鄧成輝%關泉林%薑雷%李小奇%甘亮亮%魏孔孔
산성휘%관천림%강뢰%리소기%감량량%위공공
胃肿瘤%药物疗法%多态性,单核苷酸%Meta分析%谷胱甘肽S转移酶pi
胃腫瘤%藥物療法%多態性,單覈苷痠%Meta分析%穀胱甘肽S轉移酶pi
위종류%약물요법%다태성,단핵감산%Meta분석%곡광감태S전이매pi
Stomach neoplasms%Drug therapy%Polymorphism,single nucleotide%Meta-analysis%Glutathione S-transferase pi
目的 定量评价进展期胃癌患者中谷胱甘肽S转移酶pi(GSTP1)基因105氨基酸位点Ile/Val多态性与铂类药物化疗敏感性的关系.方法 检索中国期刊全文数据库(CNKI)、中文科技期刊全文数据库(VIP)、中国生物医学文献数据库(CBM)、万方数据库、PubMed、EMBASE、Cochrane Library,收集国内外公开发表的关于GSTP1 Ilel05Val基因多态性与胃癌铂类药物化疗敏感性关系的文献.临床有效(完全缓解+部分缓解)作为评价化疗敏感性的指标.运用RevMan 5.2进行Meta分析,计算合并比值比(OR)及95％可信区间(CI),运用Stata 12.0识别是否存在发表偏倚.结果 本研究纳入6项研究共计病例724例,Meta分析结果显示,各基因型间(GG+GAvs AA:OR=2.38,95％ CI为1.29～4.38;GG vs GA+ AA:OR=3.66,95％ CI为1.18 ～ 11.39;GG vs AA:OR=4.42,95％ CI为1.28～15.26)以及亚洲人群亚组(GG+ GA vs AA:OR=2.93,95％CI为1.33 ～ 6.48)中GSTP1 Ilel05Val多态性与化疗敏感性的差异有统计学意义.结论 GSTP1 Ile105VaI(A/G)基因多态性可能与进展期胃癌铂类化疗药物敏感性相关.
目的 定量評價進展期胃癌患者中穀胱甘肽S轉移酶pi(GSTP1)基因105氨基痠位點Ile/Val多態性與鉑類藥物化療敏感性的關繫.方法 檢索中國期刊全文數據庫(CNKI)、中文科技期刊全文數據庫(VIP)、中國生物醫學文獻數據庫(CBM)、萬方數據庫、PubMed、EMBASE、Cochrane Library,收集國內外公開髮錶的關于GSTP1 Ilel05Val基因多態性與胃癌鉑類藥物化療敏感性關繫的文獻.臨床有效(完全緩解+部分緩解)作為評價化療敏感性的指標.運用RevMan 5.2進行Meta分析,計算閤併比值比(OR)及95％可信區間(CI),運用Stata 12.0識彆是否存在髮錶偏倚.結果 本研究納入6項研究共計病例724例,Meta分析結果顯示,各基因型間(GG+GAvs AA:OR=2.38,95％ CI為1.29～4.38;GG vs GA+ AA:OR=3.66,95％ CI為1.18 ～ 11.39;GG vs AA:OR=4.42,95％ CI為1.28～15.26)以及亞洲人群亞組(GG+ GA vs AA:OR=2.93,95％CI為1.33 ～ 6.48)中GSTP1 Ilel05Val多態性與化療敏感性的差異有統計學意義.結論 GSTP1 Ile105VaI(A/G)基因多態性可能與進展期胃癌鉑類化療藥物敏感性相關.
목적 정량평개진전기위암환자중곡광감태S전이매pi(GSTP1)기인105안기산위점Ile/Val다태성여박류약물화료민감성적관계.방법 검색중국기간전문수거고(CNKI)、중문과기기간전문수거고(VIP)、중국생물의학문헌수거고(CBM)、만방수거고、PubMed、EMBASE、Cochrane Library,수집국내외공개발표적관우GSTP1 Ilel05Val기인다태성여위암박류약물화료민감성관계적문헌.림상유효(완전완해+부분완해)작위평개화료민감성적지표.운용RevMan 5.2진행Meta분석,계산합병비치비(OR)급95％가신구간(CI),운용Stata 12.0식별시부존재발표편의.결과 본연구납입6항연구공계병례724례,Meta분석결과현시,각기인형간(GG+GAvs AA:OR=2.38,95％ CI위1.29～4.38;GG vs GA+ AA:OR=3.66,95％ CI위1.18 ～ 11.39;GG vs AA:OR=4.42,95％ CI위1.28～15.26)이급아주인군아조(GG+ GA vs AA:OR=2.93,95％CI위1.33 ～ 6.48)중GSTP1 Ilel05Val다태성여화료민감성적차이유통계학의의.결론 GSTP1 Ile105VaI(A/G)기인다태성가능여진전기위암박류화료약물민감성상관.
Objective To quantitatively evaluate the association between Ile105Val polymorphism of glutathione S-transferase pi (GSTP1) and sensitivity to platinum-based chemotherapy in advanced gastric cancer.Methods The relevant published literatures about Ile105Val polymorphism of GSTP1 and sensitivity to platinum-based chemotherapy in gastric cancer were retrieved from China National Knowledge Internet (CNKI),VIP,Chinese Biomedical Literature Data (CBM),Wan-Fang databases,PubMed,EMBASE and Cochrane Library.Clinical response (complete response and partial response) was employed to estimate chemosensitivity.Meta-analysis was conducted by the RevMan 5.2 software,odds ratio (OR) with 95％ confidence interval (CI) were calculated.Publication bias was identified using Stata 12.0 software.Results A total of 724 cases from 6 case-control trials were included.The results of Meta-analysis showed the different statistical significance was found between GSTP1 Ilel05Val polymorphism and clinical response in the follow genotypes [GG+GA vs AA:OR =2.38,95％CI (1.29 ～4.38); GG vs GA + AA:OR =3.66,95％CI (1.18 ～11.39) ; GG vs AA:OR =4.42,95％ CI (1.28 ～ 15.26)] and Asian population subgroups [GG + GAvs AA:OR =2.93,95％ CI (1.33 ～ 6.48)].Conclusion Polymorphism of GSTP1 Ile105Val(A/G) may be associated with platinum-based chemosensitivity in advanced gastric cancer.
